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Description

The studies began with the determination of the optimal dosing for Cagrilintide in both chow-fed and high-fat diet (HFD)-fed wild-type (WT) mice, followed by analyses of its receptor dependence using receptor activity-modifying protein (RAMP) knockout (KO) models, and mechanistic studies involving neuronal activation and gene expression profiling [2]

Vectra-based quantitative multiplex IF (qmIF) staining and data analysis using inForm qmIF analysis with tyramide signal amplification was performed on FFPE slides of TMAs, WM CRPC patient samples and PCa AD/AI xenografts